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Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

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Abstract

The Henry reaction was performed using microwave heating within the deep eutectic solvent (DES) choline chloride/urea (ChCl/urea) which acted as both the catalyst and solvent for the reaction. The optimisation of the conditions (temperature, heating mode, time, DES) allowed 1,3-dinitropropane derivatives to be obtained via tandem Henry reaction/Michael addition, in one step from a range of different aromatic aldehydes in high yields and under mild reaction conditions.

Graphical abstract: Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

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Article information


Submitted
23 Jul 2020
Accepted
20 Aug 2020
First published
20 Aug 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

G. Colombo Dugoni, A. Sacchetti and A. Mele, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01516D

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