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Issue 31, 2020
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On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments

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Abstract

An ophiobolin F synthase homolog was discovered from Aspergillus calidoustus CBS121601. The cyclisation mechanism of this terpene synthase was investigated by extensive isotopic labelling experiments and the absolute configuration of its product ophiobolin F was elucidated by enantioselective deuteration.

Graphical abstract: On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments

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Supplementary files

Article information


Submitted
16 Jul 2020
Accepted
25 Jul 2020
First published
27 Jul 2020

Org. Biomol. Chem., 2020,18, 6072-6076
Article type
Communication

On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments

Z. Quan and J. S. Dickschat, Org. Biomol. Chem., 2020, 18, 6072
DOI: 10.1039/D0OB01470B

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