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Live-cell Imaging of Lipid Droplets by Solvatochromic Styrycoumarin Derivatives

Abstract

Lipid droplets (LDs), the lipid-rich intracellular organelles, serve to regulate many physiological processes and therefore attracted attention towards selective detection of lipid droplets. We report positively solvatochromic lipophilic dyes, based on the push-pull framework containing coumarin-pyridine heterocycles for selective live-cell imaging of lipid droplets (LDs) in Cos-7 and McA-RH7777 cells at ultralow concentrations (200 nM). The fluorescence probes show a remarkable increase in fluorescence intensity with time with the hydrophobic core of the lipid droplets contributing to the observed intensity enhancement. The simple structural framework, red-emission, strong Stokes shift (>80 nm), excellent biocompatibility highlights their significance as a versatile imaging tool for studying of Lipid droplets (LDs).

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Supplementary files

Article information


Accepted
30 Jun 2020
First published
30 Jun 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Paper

Live-cell Imaging of Lipid Droplets by Solvatochromic Styrycoumarin Derivatives

P. Jana, A. Siva, V. Soppina and S. Kanvah, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB01277G

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