Issue 34, 2020
From the journal:

Organic & Biomolecular Chemistry

Ag(i)-Mediated hydrogen isotope exchange of mono-fluorinated (hetero)arenes†

Guang-Qi Hu,a   En-Ci Li,a   Hong-Hai Zhang ORCID logo *a  and  Wei Huanga  

* Corresponding authors

a Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing Tech. University (Nanjing Tech.), 30 Puzhu Road, Nanjing 211816, P. R. China
E-mail: iamhhzhang@njtech.edu.cn

Abstract

An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by a Ag2CO3/Sphos-mediated HIE protocol with D2O as the deuterium source has been disclosed. This method showed a specific site selectivity of deuteration at the α-position of the fluorine atom, which is complementary to the existing transition metal-catalyzed HIE process.

Graphical abstract: Ag(i)-Mediated hydrogen isotope exchange of mono-fluorinated (hetero)arenes

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Article information

DOI
https://doi.org/10.1039/D0OB01273D
Article type
Communication
Submitted
21 Jun 2020
Accepted
11 Aug 2020
First published
12 Aug 2020

Org. Biomol. Chem., 2020,18, 6627-6633

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Ag(I)-Mediated hydrogen isotope exchange of mono-fluorinated (hetero)arenes

G. Hu, E. Li, H. Zhang and W. Huang, Org. Biomol. Chem., 2020, 18, 6627 DOI: 10.1039/D0OB01273D

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