Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Pyrazoles: ‘one-pot’ synthesis from arenes and carboxylic acids

Author affiliations

Abstract

A rapid and efficient method for ‘one-pot’ synthesis of pyrazoles from (hetero)arenes and carboxylic acids via successive formation of ketones and β-diketones followed by heterocyclization with hydrazine has been developed. The utility of the RCOOH/TfOH/TFAA acylation system for intermediate production of ketones and 1,3-diketones is a key feature of this approach. The preliminary evaluation of the anticancer activity of the synthesized pyrazoles is performed.

Graphical abstract: Pyrazoles: ‘one-pot’ synthesis from arenes and carboxylic acids

Back to tab navigation

Supplementary files

Article information


Submitted
15 Jun 2020
Accepted
29 Jun 2020
First published
30 Jun 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Pyrazoles: ‘one-pot’ synthesis from arenes and carboxylic acids

J. K. Kim, M. Gong, E. A. Shokova, V. A. Tafeenko, O. V. Kovaleva, Y. Wu and V. V. Kovalev, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01228A

Social activity

Search articles by author

Spotlight

Advertisements