Pyrazoles: 'one-pot' syntheses from arenes and carboxylic acids
A rapid and efficient method for 'one-pot' synthesis of pyrazoles from (hetero)arenes and carboxylic acids via successive formation of ketones, β-diketones with following heterocyclization with hydrazine has been developed. The utility of the RCOOH/TfOH/TFAA acylation system for intermediate production of ketones and 1,3-diketones is a key feature of this approach. The preliminary evaluation of anticancer activity of synthesized pyrazoles is performed.
- This article is part of the themed collection: Synthetic methodology in OBC