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Pyrazoles: 'one-pot' syntheses from arenes and carboxylic acids

Abstract

A rapid and efficient method for 'one-pot' synthesis of pyrazoles from (hetero)arenes and carboxylic acids via successive formation of ketones, β-diketones with following heterocyclization with hydrazine has been developed. The utility of the RCOOH/TfOH/TFAA acylation system for intermediate production of ketones and 1,3-diketones is a key feature of this approach. The preliminary evaluation of anticancer activity of synthesized pyrazoles is performed.

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Article information


Submitted
15 Jun 2020
Accepted
29 Jun 2020
First published
30 Jun 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Paper

Pyrazoles: 'one-pot' syntheses from arenes and carboxylic acids

J. K. Kim, M. Gong, E. Shokova, V. Tafeenko, O. V. Kovaleva, Y. Wu and V. Kovalev, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB01228A

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