Photochemical benzylic radical arylation promoted by supported Pd nanostructures†
We report a novel way to promote photochemical benzylic radical arylations using Pd nanostructures. Traditional benzylic radical reaction pathways are challenged by the presence of metal centres that provoke unprecedented regioselectivity towards more synthetically relevant C(sp3)–C(sp2) couplings. This new C–H activation pathway is rationalised by means of a pseudo-persistent radical effect facilitated by metal centres. We show the mechanistic and computational aspects of the heterogeneous photocatalytic processes that are the root of this drastic change in reactivity.
- This article is part of the themed collection: Catalysis & biocatalysis in OBC