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Genetic dereplication driven discovery of a tricinoloniol acid biosynthetic pathway in Trichoderma hypoxylon

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Abstract

A genetic dereplication approach in combination with differential gene expression led to the discovery of three new sesquiterpenes, tricinoloniol acids (TRAs) A–C (1–3) and the known fusidilactone A (4) from T. hypoxylon. Comparative transcriptomic analysis and targeted deletion identified the biosynthetic route for TRAs. Our results demonstrate an alternative application of the genetic dereplication method for exploring the biosynthesis of cryptic secondary metabolites (SMs), which utilizes the coordinated expression of trichothecene (tri) and tra cluster genes.

Graphical abstract: Genetic dereplication driven discovery of a tricinoloniol acid biosynthetic pathway in Trichoderma hypoxylon

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Supplementary files

Article information


Submitted
10 Jun 2020
Accepted
27 Jun 2020
First published
29 Jun 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Genetic dereplication driven discovery of a tricinoloniol acid biosynthetic pathway in Trichoderma hypoxylon

H. Liu, Y. Pu, J. Ren, E. Li, L. Guo and W. Yin, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01202E

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