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Palladium-catalyzed synthesis of 5-amino-1,2,4-oxadiazoles via isocyanide insertion

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Abstract

A convenient and efficient palladium-catalyzed approach has been developed for the synthesis of 5-amino-1,2,4-oxadiazoles from amidoximes and isocyanides. Various 5-amino-1,2,4-oxadiazoles were obtained in moderate to high yields under mild conditions. The key to the success of this strategy involves new C–N bond and C–O bond formation via palladium-catalyzed isocyanide insertion.

Graphical abstract: Palladium-catalyzed synthesis of 5-amino-1,2,4-oxadiazoles via isocyanide insertion

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Article information


Submitted
27 May 2020
Accepted
17 Jun 2020
First published
18 Jun 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Palladium-catalyzed synthesis of 5-amino-1,2,4-oxadiazoles via isocyanide insertion

X. Wang, J. Fu, J. Xie, Q. Teng, H. Tang and Y. Pan, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01092H

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