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Issue 26, 2020
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Copper-catalyzed 1,3-aminothiocyanation of arylcyclopropanes

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A copper-catalyzed 1,3-aminothiocyanation of arylcyclopropanes with N-fluorobenzenesulfonimide (NFSI) and trimethylsilyl isothiocyanate (TMSNCS) has been developed for the first time, efficiently synthesizing a series of γ-aminothiocyanate derivatives in moderate to excellent yields from readily available substrates under mild conditions. The practicability of the reaction was demonstrated by gram-scale preparation. Furthermore, the easily prepared γ-aminothiocyanate derivatives were verified to be versatile building blocks.

Graphical abstract: Copper-catalyzed 1,3-aminothiocyanation of arylcyclopropanes

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Supplementary files

Article information

22 May 2020
16 Jun 2020
First published
17 Jun 2020

Org. Biomol. Chem., 2020,18, 4932-4935
Article type

Copper-catalyzed 1,3-aminothiocyanation of arylcyclopropanes

X. Wang, L. Wang, S. Yang, L. Zhang, Y. Li and Q. Zhang, Org. Biomol. Chem., 2020, 18, 4932
DOI: 10.1039/D0OB01060J

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