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Copper(i)-catalyzed intermolecular cyanoarylation of alkenes: convenient access to α-alkylated arylacetonitriles

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Abstract

A novel Cu(I)-catalyzed intermolecular cyanoarylation of alkenes with diaryliodonium salts as a radical arylating reagent and tetra-butylammonium cyanide as an electrophilic cyanating reagent was established. A broad range of α-alkylated arylacetonitriles were efficiently constructed in good to excellent yields under base- and oxidant-free and mild conditions.

Graphical abstract: Copper(i)-catalyzed intermolecular cyanoarylation of alkenes: convenient access to α-alkylated arylacetonitriles

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Article information


Submitted
21 May 2020
Accepted
22 Jun 2020
First published
22 Jun 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Copper(I)-catalyzed intermolecular cyanoarylation of alkenes: convenient access to α-alkylated arylacetonitriles

X. Chen, Q. Gui, R. Yi, X. Yu, Z. Wu, Y. Huang, Z. Cao and W. He, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01055C

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