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Issue 26, 2020
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Selective N-monomethylation of primary anilines with the controllable installation of N-CH2D, N-CHD2, and N-CD3 units

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Abstract

The selective N-monomethylation of primary anilines was realized by the use of the Me3N-BH3/N,N-dimethylformamide (DMF) system as the methyl source. This method also allows for the controllable introduction of N-CH2D, N-CHD2, and N-CD3 units with high levels of deuterium incorporation using Me3N-BH3/d7-DMF, Me3N-BD3/DMF and Me3N-BD3/d7-DMF systems, respectively.

Graphical abstract: Selective N-monomethylation of primary anilines with the controllable installation of N-CH2D, N-CHD2, and N-CD3 units

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Article information


Submitted
21 May 2020
Accepted
12 Jun 2020
First published
12 Jun 2020

Org. Biomol. Chem., 2020,18, 4922-4926
Article type
Communication

Selective N-monomethylation of primary anilines with the controllable installation of N-CH2D, N-CHD2, and N-CD3 units

J. Meng, H. Xia, A. Xu, Y. Wang, Z. Wang and F. Zhang, Org. Biomol. Chem., 2020, 18, 4922
DOI: 10.1039/D0OB01054E

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