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Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

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Abstract

One-pot synthesis of indole-fused bicyclo[2.2.2]octanones from DiMeOIN and 2-cyclohexen-1-one is accomplished under an iodine catalyst. The simple and metal-free conditions provide a practical tool to construct Csp3-rich complex molecules via coupling cyclization.

Graphical abstract: Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

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Article information


Submitted
26 Apr 2020
Accepted
20 May 2020
First published
20 May 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

T. Abe and S. Hirao, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB01038C

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