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Issue 25, 2020
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Efficient and selective antibody modification with functionalised divinyltriazines

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Abstract

A highly efficient disulfide rebridging strategy for the modification of monoclonal antibodies with substituted divinyltriazine linkers is reported. The reaction proceeds efficiently under mild conditions with near stoichiometric quantities of linker. This method of conjugation yields serum stable antibody conjugates with a controlled payload loading of 4.

Graphical abstract: Efficient and selective antibody modification with functionalised divinyltriazines

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Supplementary files

Article information


Submitted
15 May 2020
Accepted
10 Jun 2020
First published
10 Jun 2020

This article is Open Access

Org. Biomol. Chem., 2020,18, 4739-4743
Article type
Communication

Efficient and selective antibody modification with functionalised divinyltriazines

A. J. Counsell, S. J. Walsh, N. S. Robertson, H. F. Sore and D. R. Spring, Org. Biomol. Chem., 2020, 18, 4739
DOI: 10.1039/D0OB01002B

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