Strategies for the Construction of γ-Spirocyclic Butenolides in Natural Product Synthesis
In the last four decades, the number of γ-spirocyclic butenolide containing natural products, drugs, and medicinally useful synthetic compounds were reported. In this review, we discussed diverse chemical approaches to γ-spiro butenolides and their application towards natural products synthesis. The collective perception of the various methods may allow superior approaches capable of delivering efficient synthetic approaches to γ-spiro butenolide comprising natural products and their hybrid analogues for further drug discovery and development.
- This article is part of the themed collection: Total synthesis in OBC