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Strategies for the construction of γ-spirocyclic butenolides in natural product synthesis

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Abstract

Over the last four decades, a number of γ-spirocyclic butenolide containing natural products, drugs, and medicinally useful synthetic compounds have been reported. In this review, we discuss diverse chemical approaches to synthesize γ-spiro butenolides and their application towards natural product synthesis. The collective perception of various methods may allow superior approaches capable of delivering efficient synthetic approaches to obtain γ-spiro butenolide comprising natural products and their hybrid analogues for further drug discovery and development.

Graphical abstract: Strategies for the construction of γ-spirocyclic butenolides in natural product synthesis

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Article information


Submitted
08 May 2020
Accepted
24 Jun 2020
First published
25 Jun 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Review Article

Strategies for the construction of γ-spirocyclic butenolides in natural product synthesis

S. Mandal and B. Thirupathi, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00954G

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