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Novel use of 2-BTSO2CF2H for the metal-free electrophilic difluoromethylthiolation of indoles

Abstract

Electrophilic difluoromethylthiolation of indoles with 2-BTSO2CF2H has been conducted. In the presence of (EtO)2P(O)H and TMSCl, the reaction proceeded in modest to high yields under mild conditions. This is an unprecedented application of fluoroalkyl heteroaryl sulfone as an efficient electrophilic -SCF2H synthon for the metal-free electrophilic difluoromethylthiolation.

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Supplementary files

Article information


Submitted
26 Apr 2020
Accepted
22 May 2020
First published
22 May 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Communication

Novel use of 2-BTSO2CF2H for the metal-free electrophilic difluoromethylthiolation of indoles

J. Wei, K. Bao, Y. Wang, R. Sheng and J. Hu, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB00872A

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