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Novel usage of 2-BTSO2CF2H for metal-free electrophilic difluoroalkanethiolation of indoles

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Abstract

The electrophilic difluoromethylthiolation of indoles with 2-BTSO2CF2H is developed. In the presence of (EtO)2P(O)H and TMSCl, the reaction proceeded under mild conditions to give products in modest to high yields. This is a new application of 2-BTSO2CF2H for electrophilic difluoromethylthiolation.

Graphical abstract: Novel usage of 2-BTSO2CF2H for metal-free electrophilic difluoroalkanethiolation of indoles

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Article information


Submitted
26 Apr 2020
Accepted
22 May 2020
First published
22 May 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Novel usage of 2-BTSO2CF2H for metal-free electrophilic difluoroalkanethiolation of indoles

J. Wei, K. Bao, Y. Wang, R. Sheng and J. Hu, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00872A

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