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Modular Control of L-Tryptophan Isotopic Labelling via an Efficient Biosynthetic Cascade

Abstract

Isotopologs are powerful tools for investigating biological systems. We report a biosynthetic-cascade synthesis of Trp isotopologs starting from indole, glycine, and formaldehyde using the enzymes L-threonine aldolase and an engineered β-subunit of tryptophan synthase. This modular route to Trp isotopologs is simple and inexpensive, enabling facile access to these compounds.

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Supplementary files

Article information


Submitted
25 Apr 2020
Accepted
17 May 2020
First published
18 May 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Communication

Modular Control of L-Tryptophan Isotopic Labelling via an Efficient Biosynthetic Cascade

C. M. Thompson, A. D. McDonald, H. Yang, S. Cavagnero and A. R. Buller, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB00868K

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