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Issue 21, 2020
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Conjugating pyrene onto PNA-based fluorescent probes for improved detection selectivity toward double-stranded siRNA

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Abstract

We report on the design of new siRNA-binding fluorescent probes with the improved detection selectivity toward intact double-stranded siRNAs over single-stranded forms by the conjugation of pyrene unit into thiazole orange base surrogate-carrying peptide nucleic acid (PNA) that can simultaneously recognize the 3′-overhang and double-stranded sequences of target siRNAs.

Graphical abstract: Conjugating pyrene onto PNA-based fluorescent probes for improved detection selectivity toward double-stranded siRNA

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Article information


Submitted
17 Apr 2020
Accepted
11 May 2020
First published
12 May 2020

Org. Biomol. Chem., 2020,18, 4009-4013
Article type
Communication

Conjugating pyrene onto PNA-based fluorescent probes for improved detection selectivity toward double-stranded siRNA

Y. Sato, Y. Takahashi, T. Tanabe and S. Nishizawa, Org. Biomol. Chem., 2020, 18, 4009
DOI: 10.1039/D0OB00794C

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