Yusuke Sato, Yuki Takahashi, Takaaki Tanabe and Seiichi Nishizawa
Org. Biomol. Chem., 2020,18, 4009-4013
DOI:
10.1039/D0OB00794C,
Communication
We report on the design of new siRNA-binding fluorescent probes with the improved detection selectivity toward intact double-stranded siRNAs over single-stranded forms by the conjugation of pyrene unit into thiazole orange base surrogate-carrying peptide nucleic acid (PNA) that can simultaneously recognize the 3′-overhang and double-stranded sequences of target siRNAs.
