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Issue 25, 2020
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Copper-catalyzed ortho-C(sp2)–H amination of benzamides and picolinamides with alkylamines using oxygen as a green oxidant

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Abstract

A versatile Cu-catalyzed direct ortho-C(sp2)–H amination of benzamides and picolinamides with alkylamines has been achieved. This method employs cheap and eco-friendly copper as a catalyst and oxygen as an oxidant, and also has the advantages of straightforward steps and excellent functional group compatibility. Further application of our approach was demonstrated by the synthesis of TCMDC-125116, SPHINX, and SRPIN340.

Graphical abstract: Copper-catalyzed ortho-C(sp2)–H amination of benzamides and picolinamides with alkylamines using oxygen as a green oxidant

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Article information


Submitted
16 Apr 2020
Accepted
04 Jun 2020
First published
09 Jun 2020

Org. Biomol. Chem., 2020,18, 4802-4814
Article type
Paper

Copper-catalyzed ortho-C(sp2)–H amination of benzamides and picolinamides with alkylamines using oxygen as a green oxidant

Q. Li, J. Huang, G. Chen and S. Wang, Org. Biomol. Chem., 2020, 18, 4802
DOI: 10.1039/D0OB00784F

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