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Issue 24, 2020
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Palladium catalyzed asymmetric allylic alkylation of isoquinolinedione derivatives in the preparation of quaternary carbon stereocenters

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Abstract

A highly enantioselective allylic alkylation of isoquinolinedione derivatives under palladium catalysis was developed in the preparation of quaternary carbon stereocenters. Under standard reaction conditions, excellent yields and enantioselectivities were realized and the products could be transformed into dihydroisoquinolone with vicinal chiral carbon centers or THIQ core structures in short steps with high yields.

Graphical abstract: Palladium catalyzed asymmetric allylic alkylation of isoquinolinedione derivatives in the preparation of quaternary carbon stereocenters

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Article information


Submitted
13 Apr 2020
Accepted
26 May 2020
First published
27 May 2020

Org. Biomol. Chem., 2020,18, 4551-4555
Article type
Communication

Palladium catalyzed asymmetric allylic alkylation of isoquinolinedione derivatives in the preparation of quaternary carbon stereocenters

Y. Li, C. Cheng, L. Tang and Y. Yang, Org. Biomol. Chem., 2020, 18, 4551
DOI: 10.1039/D0OB00765J

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