C-H Functionalization of Quinazolinone by Transition Metal Catalysis
Quinazolinone and its congeners are ubiquitous structural motifs found in numerous natural products due to their wide application as anticancer, antiviral, anti-inflammatory, antifloate and antitumor agents etc. Previously, synthetic community engrossed their efforts towards synthetic approaches and recent years have also observed an upsurge in the diversification of this scaffold as well as its application. Thus, this review comprehensively focuses on transition metal catalyzed C-H bond functionalization namely arylation, amination, acetoxylation, amidation, alkylation, alkenylation, alkynylation, halogenation, thiolation, trifluoroethylation etc. of quinazolinone. Additionally, we also briefly elucidate the mechanistic pathways, scope and limitations.
- This article is part of the themed collection: Synthetic methodology in OBC