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C-H Functionalization of Quinazolinone by Transition Metal Catalysis

Abstract

Quinazolinone and its congeners are ubiquitous structural motifs found in numerous natural products due to their wide application as anticancer, antiviral, anti-inflammatory, antifloate and antitumor agents etc. Previously, synthetic community engrossed their efforts towards synthetic approaches and recent years have also observed an upsurge in the diversification of this scaffold as well as its application. Thus, this review comprehensively focuses on transition metal catalyzed C-H bond functionalization namely arylation, amination, acetoxylation, amidation, alkylation, alkenylation, alkynylation, halogenation, thiolation, trifluoroethylation etc. of quinazolinone. Additionally, we also briefly elucidate the mechanistic pathways, scope and limitations.

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Article information


Submitted
09 Apr 2020
Accepted
21 May 2020
First published
21 May 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Review Article

C-H Functionalization of Quinazolinone by Transition Metal Catalysis

P. Ghosh, B. Ganguly and S. Das, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB00742K

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