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Catalyst- and solvent-free efficient access to N-alkylated amines via reductive amination using HBpin

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Abstract

A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and is compatible with a wide range of sterically and electronically diverse aldehydes and primary amines. Notably, this simple process offers scalability, excellent functional group tolerance, chemoselectivity, and is also effective at the synthesis of biologically relevant molecules.

Graphical abstract: Catalyst- and solvent-free efficient access to N-alkylated amines via reductive amination using HBpin

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Article information


Submitted
09 Apr 2020
Accepted
01 May 2020
First published
01 May 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Catalyst- and solvent-free efficient access to N-alkylated amines via reductive amination using HBpin

V. K. Pandey, S. Bauri and A. Rit, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00740D

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