Recent progress of transition metal-catalysed regioselective C–H transformations based on noncovalent interactions
Transition metal-catalysed C–H transformations are powerful methods to obtain functionalised organic molecules from simple starting materials. Controlling regioselectivity is one of the most important issues in C–H transformations. Since the remarkable work by Murai and co-workers in 1993, many groups have reported ortho-selective C(sp2)–H transformations using directing group methods, in which interactions exist between substrates and catalytically active metal centres. In this review, new methodologies to achieve regioselective C–H transformations are described. In these methhodologies, noncovalent interactions between substrates and reagents or ligands of catalysts play important roles. In these cases, selective functionalization of remote C–H bonds, such as meta- and para-C–H bonds, can also be realized.
- This article is part of the themed collection: Synthetic methodology in OBC