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Issue 20, 2020
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Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons

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Abstract

3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C promoted the nucleophilic addition of indoles to the cyclohexanones, and the subsequent dehydration and Pd/C-catalyzed dehydrogenation produced the 3-arylindoles. The additive 2,3-dimethyl-1,3-butadiene worked as a hydrogen acceptor to facilitate the dehydrogenation step.

Graphical abstract: Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons

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Article information


Submitted
03 Apr 2020
Accepted
05 May 2020
First published
07 May 2020

Org. Biomol. Chem., 2020,18, 3898-3902
Article type
Paper

Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons

K. Ban, Y. Yamamoto, H. Sajiki and Y. Sawama, Org. Biomol. Chem., 2020, 18, 3898
DOI: 10.1039/D0OB00702A

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