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A novel one-pot method for the stereoselective synthesis of tetrahydropyrimidinones in a low melting mixture

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Abstract

A direct and metal free one-pot method has been developed for the stereoselective synthesis of tetrahydropyrimidinone derivatives from a vinyl arene and formaldehyde using a tartaric acid–dimethylurea (TA : DMU) melt as a green reaction medium. The substrate scope of this method is very general and the tetrahydropyrimidinone (THPM) derivatives are synthesized in good yields with a high degree of diastereoselectivity. In this reaction, the melt plays a triple role as the solvent, catalyst and reagent.

Graphical abstract: A novel one-pot method for the stereoselective synthesis of tetrahydropyrimidinones in a low melting mixture

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Article information


Submitted
02 Apr 2020
Accepted
14 May 2020
First published
14 May 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

A novel one-pot method for the stereoselective synthesis of tetrahydropyrimidinones in a low melting mixture

P. Devi, M. R. Lambu and S. Baskaran, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00697A

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