Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Synthesis of B-ring-fluorinated (−)-epicatechin gallate derivatives

Author affiliations

Abstract

The synthesis of enantiomerically pure B-ring fluorinated catechin derivatives is presented. In a convergent approach the chromane was obtained by reaction of a lithiated fluoro-resorcine with an optically active epoxide. The latter was prepared from 3,4-difluorobenzaldehyde by reaction with vinylmagnesium bromide followed by Sharpless epoxidation. The protocol provides access to both fluorinated catechin as well as epicatechin derivatives.

Graphical abstract: Synthesis of B-ring-fluorinated (−)-epicatechin gallate derivatives

Back to tab navigation

Supplementary files

Article information


Submitted
01 Apr 2020
Accepted
13 May 2020
First published
19 May 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Synthesis of B-ring-fluorinated (−)-epicatechin gallate derivatives

D. D. S. Thieltges, K. D. Baumgarten, C. S. Michaelis and C. Czekelius, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00686F

Social activity

Search articles by author

Spotlight

Advertisements