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Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity

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Abstract

Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives. This reaction proceeds with 0.2 equiv. of nBu4NClO4 as an electrolyte and Pt working electrodes in an undivided cell, resulting in the selenyl-dihydrofurans in good to excellent yields. Furthermore, several of the synthesized products presented a high percentage of acetylcholinesterase (AChE) inhibition, highlighting their potential anti-Alzheimer activity.

Graphical abstract: Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity

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Article information


Submitted
25 Mar 2020
Accepted
21 Apr 2020
First published
21 Apr 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity

M. R. Scheide, A. R. Schneider, G. A. M. Jardim, G. M. Martins, D. C. Durigon, S. Saba, J. Rafique and A. L. Braga, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00629G

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