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Issue 26, 2020
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Asymmetric copper-catalyzed fluorination of cyclic β-keto esters in a continuous-flow microreactor

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Abstract

A highly enantioselective homogeneous fluorination of cyclic β-keto esters catalyzed by diphenylamine linked bis(oxazoline)–Cu(OTf)2 complexes has been established in a continuous flow microreactor. The microreactor allowed an efficient transformation with reaction times ranging from 0.5 to 20 min, and the desired products were afforded in high yields (up to 99%) with excellent enantioselectivities (up to 99% ee) at a low catalyst loading of 1 mol%.

Graphical abstract: Asymmetric copper-catalyzed fluorination of cyclic β-keto esters in a continuous-flow microreactor

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Supplementary files

Article information


Submitted
20 Mar 2020
Accepted
15 Jun 2020
First published
16 Jun 2020

Org. Biomol. Chem., 2020,18, 4927-4931
Article type
Communication

Asymmetric copper-catalyzed fluorination of cyclic β-keto esters in a continuous-flow microreactor

Y. Wang, Z. Jiang, M. Chu, S. Qi, H. Yin, H. Han and D. Xu, Org. Biomol. Chem., 2020, 18, 4927
DOI: 10.1039/D0OB00588F

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