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Improved total synthesis of the antibiotic A54145B

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Abstract

A54145B is a calcium-dependent cyclic lipodepsipeptide antibiotic that is active against Gram-positive pathogens. Herein, we report an improved synthetic route toward A54145B in terms of the yield and time required. The key changes include using a pre-assembled minimalist tetradepsipeptide building block to solve the difficult on-resin esterification from our previous synthetic route, and a new macrocyclization site to avoid the peptide self-cleavage problem.

Graphical abstract: Improved total synthesis of the antibiotic A54145B

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Article information


Submitted
16 Mar 2020
Accepted
07 Apr 2020
First published
07 Apr 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Improved total synthesis of the antibiotic A54145B

H. Y. Chow, D. Chen and X. Li, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00558D

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