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Issue 16, 2020
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The ruthenium(ii)-catalyzed C–H olefination of indoles with alkynes: the facile construction of tetrasubstituted alkenes under aqueous conditions

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Abstract

An environmentally-friendly and facile protocol for the construction of tetrasubstituted alkenes has been established with Ru(II)-catalyzed C–H bond functionalizations under mild conditions. The method features the usage of readily available substrates, without external oxidants and additives, 100% atom economy, and excellent regioselectivity, thus enhancing the practicability of this protocol. Moreover, this transformation proceeded smoothly under aqueous conditions and could be extended to the gram scale. N-Methoxyamide, as a directing group (DG), played a vital role in the transformation.

Graphical abstract: The ruthenium(ii)-catalyzed C–H olefination of indoles with alkynes: the facile construction of tetrasubstituted alkenes under aqueous conditions

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Supplementary files

Article information


Submitted
10 Mar 2020
Accepted
24 Mar 2020
First published
26 Mar 2020

Org. Biomol. Chem., 2020,18, 3158-3163
Article type
Paper

The ruthenium(II)-catalyzed C–H olefination of indoles with alkynes: the facile construction of tetrasubstituted alkenes under aqueous conditions

M. Li, T. Yao, S. Sun, T. Yan, L. Wen and L. Zhang, Org. Biomol. Chem., 2020, 18, 3158
DOI: 10.1039/D0OB00508H

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