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Ruthenium(II)-catalyzed C–H olefination of indoles with alkynes: facile construction of tetrasubstituted alkenes under aqueous conditions

Abstract

An environmentally-friendly and facile protocol for the construction of tetrasubstituted alkenes has been established by Ru(II)-catalyzed C-H bond functionalizations under mild conditions. The method was featured by the usage of readily available substrates, without external oxidants and additives, 100% atom economy, and excellent regioselectivity, thus enhancing the practicability of this protocol. Moreover, this transformation underwent smoothly under aqueous conditions and could be extended to gram scale. N-Methoxy amide, as a directing group (DG) played a vital role in the transformation

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Article information


Accepted
24 Mar 2020
First published
26 Mar 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Paper

Ruthenium(II)-catalyzed C–H olefination of indoles with alkynes: facile construction of tetrasubstituted alkenes under aqueous conditions

M. Li, T. Yao, S. Sun, T. Yan, L. Wen and L. Zhang, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB00508H

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