Jump to main content
Jump to site search

Issue 17, 2020
Previous Article Next Article

Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines

Author affiliations

Abstract

A new synthetic method toward direct C–N bond formation through saturated C–H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Both aminopyridines and anilines could react smoothly with primary and secondary benzylic C–H substrates or cyclohexane to form the corresponding aromatic secondary amines in moderate to good yields. This protocol has the advantages of wide functional group tolerance and use of readily available raw materials.

Graphical abstract: Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines

Back to tab navigation

Supplementary files

Article information


Submitted
07 Mar 2020
Accepted
09 Apr 2020
First published
10 Apr 2020

Org. Biomol. Chem., 2020,18, 3263-3268
Article type
Communication

Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines

H. Yao, B. Xie, X. Zhong, S. Jin, S. Lin and Z. Yan, Org. Biomol. Chem., 2020, 18, 3263
DOI: 10.1039/D0OB00491J

Social activity

Search articles by author

Spotlight

Advertisements