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Issue 18, 2020
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A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters

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Abstract

A diastereoselective three-component reaction of diazo compounds with alcohols and pyrazolinone ketimines by utilizing rhodium(II) catalysis via interception of transient oxonium ylides is reported. The reaction provides an efficient approach for the facile construction of polyfunctionalized pyrazolone derivatives bearing two contiguous quaternary stereocenters in good yields with high regioselectivities and excellent diastereoselectivities.

Graphical abstract: A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters

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Article information


Submitted
06 Mar 2020
Accepted
10 Apr 2020
First published
13 Apr 2020

Org. Biomol. Chem., 2020,18, 3466-3470
Article type
Communication

A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters

C. Ao, J. Huang, X. Xu, S. Jia, Z. Kang and W. Hu, Org. Biomol. Chem., 2020, 18, 3466
DOI: 10.1039/D0OB00482K

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