Jump to main content
Jump to site search


Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis

Author affiliations

Abstract

The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.

Graphical abstract: Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis

Back to tab navigation

Supplementary files

Article information


Submitted
05 Mar 2020
Accepted
24 Mar 2020
First published
24 Mar 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis

M. Sicignano, R. I. Rodríguez, V. Capaccio, F. Borello, R. Cano, F. De Riccardis, L. Bernardi, S. Díaz-Tendero, G. Della Sala and J. Alemán, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00476F

Social activity

Search articles by author

Spotlight

Advertisements