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Asymmetric Trifluoromethylthiolation of Azlactones under Chiral Phase Transfer Catalysis

Abstract

The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.

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Accepted
24 Mar 2020
First published
24 Mar 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Paper

Asymmetric Trifluoromethylthiolation of Azlactones under Chiral Phase Transfer Catalysis

M. Sicignano, R. I. Rodriguez, V. Capaccio, F. Borello, R. Cano Monserrat, F. De Riccardis, L. Bernardi, S. Díaz-Tendero, G. Della Sala and J. Aleman, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB00476F

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