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Issue 17, 2020
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Synthetic pathways to tetrahydrocannabinol (THC): an overview

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Abstract

The therapeutic effects of molecules produced by the plant species Cannabis sativa have since their discovery captured the interest of scientists and society, and have spurred the development of a multidisciplinary scientific field with contributions from biologists, medical specialists and chemists. Decades after the first isolation of some of the most bioactive tetrahydrocannabinols, current research is mostly dedicated to exploiting the chemical versatility of this relevant compound class with regard to its therapeutic potential. This review will primarily focus on synthetic pathways utilised for the synthesis of tetrahydrocannabinols and derivatives thereof, including chiral pool-based and asymmetric chemo- and biocatalytic approaches.

Graphical abstract: Synthetic pathways to tetrahydrocannabinol (THC): an overview

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Article information


Submitted
03 Mar 2020
Accepted
31 Mar 2020
First published
31 Mar 2020

This article is Open Access

Org. Biomol. Chem., 2020,18, 3203-3215
Article type
Review Article

Synthetic pathways to tetrahydrocannabinol (THC): an overview

V. R. L. J. Bloemendal, J. C. M. van Hest and F. P. J. T. Rutjes, Org. Biomol. Chem., 2020, 18, 3203
DOI: 10.1039/D0OB00464B

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