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Stereoselective Preparation of P,Axial-Stereogenic Allenyl Bisphosphine Oxides via Chirality-Transferring

Abstract

P,C-Stereogenic propargyl alcohols RC-3/SC-3’ were prepared from the addition of (L)-menthyl-derived SPOs to propynals, which were converted to P,axial-stereogenic allenyl bisphosphine oxides. The chirality transferring was controlled by alpha-carbon via syn [2,3]-sigmatropic rearrangement. For SC-3’ linking weak WDG on alkynyl moiety, the chirality on axis was controlled by stereogenic phosphorus.

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Article information


Submitted
07 Mar 2020
Accepted
24 Mar 2020
First published
25 Mar 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Communication

Stereoselective Preparation of P,Axial-Stereogenic Allenyl Bisphosphine Oxides via Chirality-Transferring

C. Zhao, M. Qiu, H. Zheng, J. Ye, B. Yan and Q. Li, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB00390E

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