Stereoselective Preparation of P,Axial-Stereogenic Allenyl Bisphosphine Oxides via Chirality-Transferring
P,C-Stereogenic propargyl alcohols RC-3/SC-3’ were prepared from the addition of (L)-menthyl-derived SPOs to propynals, which were converted to P,axial-stereogenic allenyl bisphosphine oxides. The chirality transferring was controlled by alpha-carbon via syn [2,3]-sigmatropic rearrangement. For SC-3’ linking weak WDG on alkynyl moiety, the chirality on axis was controlled by stereogenic phosphorus.
- This article is part of the themed collection: Synthetic methodology in OBC