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Rh-catalyzed C-H activation/intramolecular condensation for construction of benzo[f]pyrazolo[1,5-a][1,3]diazepines

Abstract

A novel and mild Rh(III)-catalyzed C-H activation/intramolecular condensation of 1-aryl-1H-pyrazol-5-amines with cyclic 2-diazo-1,3-diketones was developed, giving access to various important benzo[f]pyrazolo[1,5-a][1,3]diazepine scaffolds through sequential C-C/C-N bond formation in one-pot procedure under additive- and oxidant-free conditions. Furthermore, 3-([1,1'-biphenyl]-2-ylamino)-2-ethoxycyclohex-2-enones can be obtained in good yields by constructing C-O and C-N bonds through 1,1′-insertion, dehydration, and isomerization process.

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Article information


Submitted
21 Feb 2020
Accepted
20 Mar 2020
First published
20 Mar 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Paper

Rh-catalyzed C-H activation/intramolecular condensation for construction of benzo[f]pyrazolo[1,5-a][1,3]diazepines

Y. Ning, X. He, Y. Zuo, J. Wang, Q. Tang, M. Xie, R. Li and Y. Shang, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB00382D

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