Jump to main content
Jump to site search


Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution

Author affiliations

Abstract

Ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution (DYRKR) of α-substituted-β-keto arylphosphonates was developed as a generic and stereoselective approach to synthesize chiral α-substituted-β-hydroxy arylphosphonates, with moderate-to-excellent isolated yield (up to 96%), good-to-excellent diastereoselectivity (up to >99 : <1 dr), and excellent enantioselectivity (up to >99% ee) being achieved.

Graphical abstract: Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution

Back to tab navigation

Supplementary files

Article information


Submitted
20 Feb 2020
Accepted
16 Mar 2020
First published
16 Mar 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution

Z. Wang, Y. Zeng, X. Wu, Z. Li, Y. Tao, X. Yu, Z. Huang and F. Chen, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00379D

Social activity

Search articles by author

Spotlight

Advertisements