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Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives

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Abstract

A one-pot protocol has been developed for the synthesis of quinazolinones from amide-oxazolines with TsCl via a cyclic 1,3-azaoxonium intermediate and 6π electron cyclization in the presence of a Lewis acid and base. The process is operationally simple and has a broad substrate scope. This method provides a unique strategy for the construction of quinazolinones.

Graphical abstract: Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives

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Article information


Submitted
03 Feb 2020
Accepted
14 May 2020
First published
16 May 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives

F. Hu, X. Cui, G. Lu and G. Huang, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00225A

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