Fang-Peng Hu, Xin-Feng Cui, Guo-Qiang Lu and Guo-Sheng Huang
Org. Biomol. Chem., 2020,18, 4376-4380
DOI:
10.1039/D0OB00225A,
Communication
A one-pot protocol has been developed for the synthesis of quinazolinones from amide-oxazolines with TsCl via a cyclic 1,3-azaoxonium intermediate and 6π electron cyclization in the presence of a Lewis acid and base. The process is operationally simple and has a broad substrate scope. This method provides a unique strategy for the construction of quinazolinones.