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Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives†

Fang-Peng Hu,a   Xin-Feng Cui,a   Guo-Qiang Lua  and  Guo-Sheng Huang ORCID logo *a  
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* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou 730000, China
E-mail: hgs@lzu.edu.cn

Abstract

A one-pot protocol has been developed for the synthesis of quinazolinones from amide-oxazolines with TsCl via a cyclic 1,3-azaoxonium intermediate and 6π electron cyclization in the presence of a Lewis acid and base. The process is operationally simple and has a broad substrate scope. This method provides a unique strategy for the construction of quinazolinones.

Graphical abstract: Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives

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Article information

https://doi.org/10.1039/D0OB00225A
Submitted
03 Feb 2020
Accepted
14 May 2020
First published
16 May 2020
Org. Biomol. Chem., 2020, Advance Article
Article type
Communication
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Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives

F. Hu, X. Cui, G. Lu and G. Huang, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00225A

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