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Issue 10, 2020
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Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

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Abstract

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.

Graphical abstract: Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

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Article information


Submitted
31 Jan 2020
Accepted
06 Feb 2020
First published
06 Feb 2020

Org. Biomol. Chem., 2020,18, 1881-1885
Article type
Communication

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

J. C. Maza, A. V. Ramsey, M. Mehare, S. W. Krska, C. A. Parish and M. B. Francis, Org. Biomol. Chem., 2020, 18, 1881
DOI: 10.1039/D0OB00211A

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