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Secondary Modification of Oxidatively-Modified Proline N-termini for the Construction of Complex Bioconjugates

Abstract

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine- bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bionconjugates are constructed and proline N-terminal proteins are immobilized.

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Article information


Accepted
06 Feb 2020
First published
06 Feb 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Communication

Secondary Modification of Oxidatively-Modified Proline N-termini for the Construction of Complex Bioconjugates

J. C. Maza, A. V. Ramsey, M. Mehare, S. Krska, C. A. Parish and M. B. Francis, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0OB00211A

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