Jump to main content
Jump to site search


Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3,6Galβ1 → 4Glc

Author affiliations

Abstract

The first chemical synthesis of lacto-N-neohexaose (LNnH) has been completed using a convergent synthetic strategy. The reaction conditions and donor–acceptor combinations have been carefully refined to minimize side reactions and achieve high yields in all glycosylation steps. Lacto-N-neotetraose, another common human milk oligosaccharide, was also synthesized en route to the target LNnH.

Graphical abstract: Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3,6Galβ1 → 4Glc

Back to tab navigation

Supplementary files

Article information


Submitted
25 Jan 2020
Accepted
06 Feb 2020
First published
06 Feb 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3,6Galβ1 → 4Glc

M. D. Bandara, K. J. Stine and A. V. Demchenko, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00172D

Social activity

Search articles by author

Spotlight

Advertisements