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Issue 13, 2020
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18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain

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Abstract

Dihydromethidine (DHM) labeled with 18F at the para position of the peripheral benzene ring was designed as a positron emission tomography (PET) radiotracer for non-invasive imaging of reactive oxygen species (ROS). This compound readily crosses the blood–brain barrier and is oxidized by ROS, and the oxidation product is retained intracellularly. PET imaging of ROS-producing rat brain microinfused with sodium nitroprusside identified specific brain regions with high ROS concentrations. This tracer should be useful for studies of the pathophysiological roles of ROS, and in the diagnosis of neurodegenerative diseases.

Graphical abstract: 18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain

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Supplementary files

Article information


Submitted
20 Jan 2020
Accepted
11 Feb 2020
First published
17 Feb 2020

Org. Biomol. Chem., 2020,18, 2387-2391
Article type
Communication

18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain

H. Egami, S. Nakagawa, Y. Katsura, M. Kanazawa, S. Nishiyama, T. Sakai, Y. Arano, H. Tsukada, O. Inoue, K. Todoroki and Y. Hamashima, Org. Biomol. Chem., 2020, 18, 2387
DOI: 10.1039/D0OB00126K

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