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A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe

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Abstract

Reported herein is a fluorogenic probe for the detection of carbapenemase activity. This reagent features carbapenem as an enzyme recognition motif and a carbon–carbon double bond between carbapenem and the fluorophore, exhibiting high specificity to all carbapenemases, including metallo carbapenemases and serine carbapenemases, over other β-lactamases.

Graphical abstract: A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe

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Supplementary files

Article information


Submitted
18 Jan 2020
Accepted
11 May 2020
First published
11 May 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe

J. Wang, W. Xu, S. Xue, T. Yu and H. Xie, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00114G

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