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Rust-derived Fe2O3 nanoparticles as a green catalyst for the one-pot synthesis of hydrazinyl thiazole derivatives

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Abstract

In the present work, novel one-pot multicomponent reactions of tosylates, aryl aldehydes and thiosemicarbazide are reported for the synthesis of hydrazinyl thiazoles, using Fe2O3 NPs derived from rusted iron as a catalyst. The Fe2O3 NPs were characterized using XRD, SEM, VSM, HR-TEM, EDX and FT-IR techniques. The structures of all of the synthesized hydrazinyl thiazole derivatives were confirmed by 1H NMR, 13C NMR, FT-IR and mass spectrometry. The magnetic Fe2O3 NPs were easily recovered from the reactions using an external magnet, and the catalytic activity of the recycled catalyst was examined over four cycles under optimized reaction conditions; it exhibited minimal loss of yield. To explore potential applications, the synthesized molecules were investigated for their antibacterial, antifungal and antioxidant activities, and they showed promising results. The results were further supported through molecular docking studies.

Graphical abstract: Rust-derived Fe2O3 nanoparticles as a green catalyst for the one-pot synthesis of hydrazinyl thiazole derivatives

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Supplementary files

Article information


Submitted
17 Jan 2020
Accepted
26 Mar 2020
First published
31 Mar 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Rust-derived Fe2O3 nanoparticles as a green catalyst for the one-pot synthesis of hydrazinyl thiazole derivatives

R. Gurav, S. K. Surve, S. Babar, P. Choudhari, D. Patil, V. More, S. Sankpal and S. Hangirgekar, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00109K

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