Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 25, 2020
Previous Article Next Article

Rational design of fluorescent probes for targeted in vivo nitroreductase visualization

Author affiliations

Abstract

Nitroreductase (NTR) has been recognized as a biomarker for identifying the hypoxic status of cancers. Therefore, it is of high scientific interest to design effective fluorescent probes for tracking NTR activity. However, studies on elucidation of the structure−performance relationship of fluorescent probes and those providing valuable insight into optimized probe design have rarely been reported. Three BODIPY based fluorescent probes were made by conjugation of para-, ortho-, and meta-nitrobenzene to the BODIPY core via a thiolether bond, respectively. Our study revealed that the linkage and nitro substituent position significantly influence the capability of nitroreductase detection.

Graphical abstract: Rational design of fluorescent probes for targeted in vivo nitroreductase visualization

Back to tab navigation

Supplementary files

Article information


Submitted
15 Jan 2020
Accepted
09 Jun 2020
First published
10 Jun 2020

Org. Biomol. Chem., 2020,18, 4744-4747
Article type
Communication

Rational design of fluorescent probes for targeted in vivo nitroreductase visualization

J. Gao, X. Yin, M. Li, J. Chen, J. Tan, Z. Zhao and X. Gu, Org. Biomol. Chem., 2020, 18, 4744
DOI: 10.1039/D0OB00082E

Social activity

Search articles by author

Spotlight

Advertisements