Issue 25, 2020

Rational design of fluorescent probes for targeted in vivo nitroreductase visualization

Abstract

Nitroreductase (NTR) has been recognized as a biomarker for identifying the hypoxic status of cancers. Therefore, it is of high scientific interest to design effective fluorescent probes for tracking NTR activity. However, studies on elucidation of the structure−performance relationship of fluorescent probes and those providing valuable insight into optimized probe design have rarely been reported. Three BODIPY based fluorescent probes were made by conjugation of para-, ortho-, and meta-nitrobenzene to the BODIPY core via a thiolether bond, respectively. Our study revealed that the linkage and nitro substituent position significantly influence the capability of nitroreductase detection.

Graphical abstract: Rational design of fluorescent probes for targeted in vivo nitroreductase visualization

Supplementary files

Article information

Article type
Communication
Submitted
15 Jan 2020
Accepted
09 Jun 2020
First published
10 Jun 2020

Org. Biomol. Chem., 2020,18, 4744-4747

Rational design of fluorescent probes for targeted in vivo nitroreductase visualization

J. Gao, X. Yin, M. Li, J. Chen, J. Tan, Z. Zhao and X. Gu, Org. Biomol. Chem., 2020, 18, 4744 DOI: 10.1039/D0OB00082E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements