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Cobalt-catalyzed regioselective hydrohydrazination of epoxides

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Abstract

Using an air-stable cobalt catalyst [Cp*Co(1,2-Ph2PC6H4S)(NCMe)]BF4 (1, Cp* = Me5C5), we have achieved catalytic regioselective hydrohydrazination of epoxides to 1,1-hydrazinoalcohols in an atom-economical manner. The catalysis involves a cobalt–hydrazine intermediate, in which the NH2 group of the hydrazine binds to the metal center, inhibiting its nucleophilic reactivity and allowing the NH group to participate in the regioselective hydrohydrazination.

Graphical abstract: Cobalt-catalyzed regioselective hydrohydrazination of epoxides

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Article information


Submitted
08 Jan 2020
Accepted
03 Feb 2020
First published
03 Feb 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Cobalt-catalyzed regioselective hydrohydrazination of epoxides

X. Liu, H. Song, X. Zhai, C. Tung and W. Wang, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00037J

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