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Issue 12, 2020
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Tandem transformations and multicomponent reactions utilizing alcohols following dehydrogenation strategy

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Abstract

The construction of new C–C, C–N and C–O bonds by replacing hazardous and waste generating chemicals with alcohols as the greener and sustainable reagents is one of the emerging areas of research. In consequence, the borrowing hydrogen and acceptorless dehydrogenative coupling principles have received significant momentum to synthesize various alkylated molecules and N-heterocycles. In the tandem transformations and multi-component reactions, simple substrates are directly converted to new functionalities or complex molecular systems using a single reaction set-up. In this review, the progress of tandem transformation of nitro, nitrile and azide functionalities as well as multi-component reactions utilizing alcohols is summarised. These transformations lead to the atom-economical synthesis of a wide range of alkylated imines, amines, amides and N-heterocycles such as pyrrole, pyridine, pyrimidine, quinoxaline, etc.

Graphical abstract: Tandem transformations and multicomponent reactions utilizing alcohols following dehydrogenation strategy

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Article information


Submitted
30 Dec 2019
Accepted
16 Feb 2020
First published
17 Feb 2020

Org. Biomol. Chem., 2020,18, 2193-2214
Article type
Review Article

Tandem transformations and multicomponent reactions utilizing alcohols following dehydrogenation strategy

B. Paul, M. Maji, K. Chakrabarti and S. Kundu, Org. Biomol. Chem., 2020, 18, 2193
DOI: 10.1039/C9OB02760B

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